After opening, how long is a ready-to-drink shake safe to drink? August 20, 2020 22:48 Updated Our ready-to-drink shakes should be consumed within 2 hours of opening if they are not refrigerated. After opening and if refrigerated, they should be consumed within 72 hours. Related articles What is the shelf life of Orgain ready-to-drink shakes? How should I store the Orgain ready-to-drink shakes? After mixing powder with liquid, how long is the mixed shake or smoothie safe to drink? What is the shelf life of Orgain protein powder? Why do I need to shake the ready-to-drink shakes?