After opening, how long is an Orgain ready-to-drink shake safe to drink? June 20, 2022 23:24 Updated Orgain ready-to-drink shakes should be consumed within 2 hours of opening if they are not refrigerated. After opening and if refrigerated, the Orgain ready-to-drink shake should be consumed within 72 hours. Related articles What is the shelf life of Orgain ready-to-drink shakes? How should I store the Orgain ready-to-drink shakes? After mixing the Orgain protein powder with liquid, how long is the mixed shake or smoothie safe to drink? What is the shelf life and how should I store the Orgain protein powder? Why do I need to shake the ready-to-drink shakes?