After mixing powder with liquid, how long is the mixed shake or smoothie safe to drink? August 20, 2020 22:54 Updated If not refrigerated, after mixing the powder with liquid to make a shake/smoothie it should be consumed within 2 hours. If refrigerated after mixing, it should be consumed within 24 hours. Related articles After opening, how long is the protein powder safe to consume? What is the shelf life of Orgain ready-to-drink shakes? After opening, how long is a ready-to-drink shake safe to drink? After opening, how long is the almond milk safe to drink? How should I store the Orgain protein powder?