After mixing the Orgain protein powder with liquid, how long is the mixed shake or smoothie safe to drink? June 20, 2022 23:21 Updated If not refrigerated, after mixing the powder with liquid to make a shake/smoothie it should be consumed within 2 hours. If refrigerated after mixing, it should be consumed within 24 hours. Related articles After opening, how long is an Orgain ready-to-drink shake safe to drink? I see tiny black specs or dots in my protein powder, what is that? What is the shelf life and how should I store the Orgain protein powder? Why do you use erythritol as a sweetener? I mixed Orgain MCT Oil containing product in a Styrofoam cup and it melted, why?